The β<sub>2</sub>-adrenergic receptor (<i>Adrb2</i>) entrains circadian gene oscillation and CD8<sup>+</sup> T cell differentiation in response to virus infection.
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ABSTRACT: Adaptive immune cells are regulated by circadian rhythms both under steady state conditions and during responses to infection. Cytolytic CD8+ T cells display variable responses to infection depending upon the time of day of exposure. However, the neuronal signals that entrain these cyclic behaviors remain unknown. Immune cells express various neurotransmitter receptors, and we demonstrate that selective deletion of the β2-adrenergic receptor (Adrb2) gene perturbs the normal diurnal oscillation of clock gene expression in CD8+ T cells, such as Per2 and Bmal1. Consequently, their time-of-day-dependent response to vesicular stomatitis virus was dysregulated, and the diurnal development of CD8+ T cells into variegated populations
SUBMITTER: Sharma D
PROVIDER: S-EPMC12309669 | biostudies-literature | 2025 Aug
REPOSITORIES: biostudies-literature
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