Magnetically induced magnetosome chain (MAGiC): A biogenic magnetic-particle-imaging tracer with high performance and navigability.

ABSTRACT: Magnetic particle imaging (MPI) enables real-time, sensitive, and quantitative visualization of tracer distribution, augmenting the capability of in vivo imaging technologies. Previous MPI tracer research has predominantly focused on superparamagnetic nanoparticles, whose suboptimal sigmoidal magnetization curves limit their spatial resolution. Here, we introduce the magnetically induced magnetosome chain (MAGiC), a superferromagnetic MPI tracer, demonstrating a 25-fold improvement in resolution in the excitation direction and an order of magnitude improvement in signal intensity compared to the commercial tracer VivoTrax+. Under a gradient field of 4 tesla per meter, the resolution in the excitation direction reached 80 micrometers. Furthermore, MAGiC can be accurately manipulated using m

SUBMITTER: Li L 

PROVIDER: S-EPMC12309696 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature