Targeting PGE2 mediated senescent neuron improves tumor therapy.

ABSTRACT:

Background

Recent studies have highlighted bidirectional signaling between tumors and neurons; however, the interactions between tumors and neurons in response to radio-/chemotherapy remain obscure, which hampers the tumor treatment.

Methods

Glioblastoma organoids (GBOs) and primary neuron coculture, targeted metabonomics, RNA pulldown, mass spectrum, co-immunoprecipitation, RNA-sequencing, transcript/protein validations, and multi-electrode arrays were performed to analyze neuron-tumor interaction in response to therapy. In vivo validations were conducted in orthotopic mouse models. Diagnostic and prognostic values were evaluated in serum, tissue microarray as well as The Cancer Genome Atlas (TCGA).

Results

GBOs recruited and induced pro-tumor-survival senescent neur

SUBMITTER: Zhao J 

PROVIDER: S-EPMC12309717 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature