Achieving robust labeling above the circle of Willis with vessel-encoded arterial spin labeling.

ABSTRACT:

Purpose

To improve the robustness of noninvasive vessel-selective perfusion imaging and angiography using vessel-encoded arterial spin labeling (VEASL) when applied to complex vascular geometries, such as above the circle of Willis (CoW) in the brain.

Methods

Our proposed improved optimized encoding scheme (IOES) better accounts for vascular geometry and the VEASL encoding process, leading to more SNR-efficient encodings than previous approaches. Pseudo-continuous arterial spin labeling (PCASL) parameters were optimized for a thinner labeling region, allowing tortuous vessels to be more accurately treated as single points within the labeling plane. Our optimized approach was compared to the original OES method above the CoW in healthy volunteers, with preliminary application

SUBMITTER: Li H 

PROVIDER: S-EPMC12309872 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature