MRI-based quantification of whole-organ renal metabolic rate of oxygen during free-breathing.

ABSTRACT:

Purpose

Renal metabolic rate of oxygen (rMRO₂) reflects the kidney's metabolic efficiency, making it a potential biomarker for early-stage kidney disease. This study introduces an ungated, free-breathing MRI sequence in comparison to its breath-hold counterpart to noninvasively measure whole-organ rMRO₂.

Methods

Free-breathing (FB) K-MOTIVE sequence (kidney metabolism of oxygen via T₂ and interleaved velocity encoding) was developed to simultaneously measure renal blood flow rate (BFR) and T₂ of blood water using the conservation of mass. T₂ is converted to venous oxygen saturation (SvO₂) using a calibration curve. Compared to previous versions, FB K-MOTIVE minimizes respiratory motion artifacts by acquiring f

SUBMITTER: Kamona N 

PROVIDER: S-EPMC12309874 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature