Astrocyte secretome remodeling under iron deficiency: potential implications for brain iron homeostasis.

ABSTRACT: The brain is the most metabolically active organ in the body and has a high demand for iron. Iron deficiency impairs brain function and is linked to various neurological disorders. To maintain iron homeostasis, astrocytes respond to iron levels and signal brain microvascular endothelial cells (BMVECs), which regulate iron import into the brain. However, the specific signaling molecules released by astrocytes remain largely unknown. In this study, we addressed this by performing a global proteomic analysis of the secretome of primary mouse astrocytes cultured under iron-deficient conditions. Quantitative mass spectrometry demonstrated significant remodeling of the astrocyte secretome in response to iron deficiency, affecting critical pathways related to metabolic reprogramming, stress respo

SUBMITTER: Duhaini M 

PROVIDER: S-EPMC12309891 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature