Improving quantitative BOLD-based measures of oxygen extraction fraction using hyperoxia BOLD-derived measures of blood volume.

ABSTRACT:

Purpose

Streamlined quantitative BOLD (sqBOLD) is a refinement of the quantitative BOLD (qBOLD) technique capable of producing noninvasive and quantitative maps of oxygen extraction fraction (OEF) in a clinically feasible scan time. However, sqBOLD measurements of OEF have been reported as being systematically lower than expected in healthy brain. Because the qBOLD framework infers OEF from the ratio of the reversible transverse relaxation rate ( R2'$$ {\mathrm{R}}_2^{\prime } $$ ) and deoxygenated blood volume (DBV), this underestimation has been attributed the overestimation of DBV. Therefore, this study proposes the use of an independent measure of DBV using hyperoxia BOLD and investigates whether this results in improved estimates of OEF.

Methods

Monte Carlo simulations

SUBMITTER: Stone AJ 

PROVIDER: S-EPMC12309898 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature