Risk factors, protective factors, peripheral biomarkers, and neurocognitive markers associated with mood disorders: An umbrella review of 103 meta-analyses and systematic reviews.

ABSTRACT:

Background

Mood disorders, including bipolar disorder (BD) and major depressive disorder (MDD), are extensively studied regarding environmental risk factors, protective factors, peripheral biomarkers, and cognitive neurocognitive markers. Our umbrella review of observational studies aims to separately elucidate these associations with BD and MDD.

Methods

A comprehensive search of PubMed, Embase, Web of Science, and Cochrane was conducted, with a search end date of October 17, 2024. We included systematic reviews that provided meta-analyses of observational studies that examined associations of potential environmental risk factors, environmental protective factors, peripheral biomarkers and neurocognitive markers with mood disorder. We synthesized data using summary effect es

SUBMITTER: Wang H 

PROVIDER: S-EPMC12309926 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature