Gene expression profiling in a retrospective real-world cohort of breast cancer brain metastases and paired primary tumors identifies biological changes with potential therapeutic implications.

ABSTRACT:

Background

Despite the clinical impact of breast cancer (BC) brain metastases (BMs), their biological complexity remains poorly understood. We evaluated the genomic profile of BCBMs and compared it with paired primary BC samples to characterize biological changes during brain metastasization and their clinical impact in a retrospective real-world cohort.

Materials and methods

Expression of 758 genes (BC360 Panel, nCounter), hormone receptor (HR) status, and human epidermal growth factor receptor type 2 (HER2) status were evaluated in BCBMs and matched primary BCs. Intrinsic subtyping was determined using the PAM50 subtype predictor. Gene expression/PAM50 signature and overall survival (OS) correlations were analyzed using Cox models. Median OS was calculated using the Kaplan

SUBMITTER: Griguolo G 

PROVIDER: S-EPMC12309939 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature