Effects of Podocyte Foot Process Effacement on Kidney Prognosis and Response to Immunosuppressive Therapy in IgA Nephropathy.

ABSTRACT:

Rationale & objective

Recent studies have proposed that podocyte lesions within segmental glomerulosclerosis (S1) lesions are associated with kidney prognosis in immunoglobulin A nephropathy (IgAN). However, there is a lack of research exploring the effect of podocyte lesions through electron microscopy, which is currently regarded as the best power tool for evaluating podocyte injury, on kidney prognosis and response to immunosuppressive therapy (IST).

Study design

An observational cohort study.

Setting & participants

Total of 976 patients with IgAN and at least 12 months of follow-up at Peking University First Hospital.

Exposure

Different foot process effacement (FPE) severity evaluated by electron microscopy: mild: <50%, moderate: 50%-74%, and severe: ≥75%.<

SUBMITTER: Guo Y 

PROVIDER: S-EPMC12309955 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature