HHV-6 and EBV reactivation in relapsing remitting multiple sclerosis: Disability, progression, and inflammation links.

ABSTRACT: Reactivation of human herpesvirus 6 (HHV-6) and Epstein-Barr virus (EBV) is observed in multiple sclerosis (MS). This study investigates immunoglobulins (Ig)G, IgM, and IgA responses to EBV nuclear antigen EBNA (peptide 386-405), HHV-6 (peptide 300-322) and EBV (peptide 243-268) deoxyuridine-triphosphatase (dUTPase), and different immune profiles in 58 patients with relapsing remitting MS (RRMS) compared to 60 healthy controls. IgA/IgG/IgM were measured utilizing enzyme-linked immunosorbent assays, and cytokines, chemokines, and growth factors utilizing multiplex immunoassays. RRMS patients showed significantly increased IgG, IgA, and IgM responses to all three viral antigens. IgG and IgM to HHV-6 dUTPase discriminated RRMS patients from controls with 91.5% accuracy. Neural network analysi

SUBMITTER: Almulla AF 

PROVIDER: S-EPMC12309957 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature