Association of serum Klotho with tinnitus prevalence, duration and severity: A cross-sectional study in middle-aged and older adults.

ABSTRACT:

Background

As an anti-aging protein, although studies increasingly suggest that the Klotho plays a role in the auditory system, the link between serum Klotho levels and tinnitus remains poorly characterized. The aim of this study was to investigate the associations between serum Klotho levels and tinnitus focusing on prevalence, duration and severity in middle-aged and older adults.

Methods

We performed a population-based cross-sectional study of individuals in the National Health and Nutrition Examination Survey (NHANES) 2009-2012 and 2015-2016. Univariable and multivariable logistic regression was used to evaluate the relationship between serum Klotho levels and tinnitus, with adjustment for potential confounders and further age-stratified analyses. Restricted cubic spline

SUBMITTER: Du KJ 

PROVIDER: S-EPMC12309988 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature