Association of serum lysophosphatidylcholine acyltransferase 3 levels with metabolic variables and risk of type 2 diabetes mellitus: A cross-sectional study.

ABSTRACT:

Aims

This study aimed to explore the role of serum lysophosphatidylcholine acyltransferase 3 (LPCAT3) in glucose and lipid metabolism and its association with type 2 diabetes mellitus (T2DM).

Methods

Between July and December 2024, we recruited 256 newly diagnosed T2DM patients and 252 gender- and age-matched individuals with normal glucose tolerance (NGT). Serum LPCAT3 levels were measured using ELISA. Group comparisons were conducted via t-tests or Mann-Whitney U tests. Spearman correlation analysis assessed the relationship between LPCAT3 and metabolic variables. Linear regression identified independent predictors of LPCAT3 levels. Partial Least Squares (PLS) analysis evaluated the correlations between serum LPCAT3 and obesity-related anthropometric indicators, blood gluc

SUBMITTER: Zhu H 

PROVIDER: S-EPMC12310000 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature