Dominant ionic currents in rabbit ventricular action potential dynamics.

ABSTRACT: Mathematical models of cardiac cell electrical activity include numerous parameters, making calibration to experimental data and individual-specific modeling challenging. This study applies Sobol sensitivity analysis, a global variance-decomposition method, to identify the most influential parameters in the Shannon model of rabbit ventricular myocyte action potential (AP). The analysis highlights the background chloride current ([Formula: see text]) as the dominant determinant of AP variability. Additionally, the inward rectifier potassium current ([Formula: see text]), fast/slow delayed rectifier potassium currents (IKr, [Formula: see text]), sodium-calcium exchanger current ([Formula: see text]), the slow component of the transient outward potassium current ([Formula: see text]), and L-t

SUBMITTER: Yang Z 

PROVIDER: S-EPMC12310051 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature