Matrix-assisted autologous chondrocyte transplantation is effective at mid/long-term for knee lesions: A systematic review and meta-analysis.

ABSTRACT:

Purpose

This systematic review with meta-analysis evaluates the long-term efficacy of matrix-assisted autologous chondrocyte transplantation (MACT) in terms of functional scores using scaffolds made of hyaluronic acid (HA) or collagen (C).

Methods

Nineteen articles met the eligibility criteria for the analysis. Fourteen studies focused on patients treated with MACT with HA-based scaffolds, four studies with C-based scaffolds, and one study compared both scaffold types.

Results

A higher percentage of patients in the HA subgroup had undergone previous cartilage repair procedures, whereas multiple lesions were more common in the C subgroup. Both HA- and C-treated patients showed significant functional improvement in terms of International Knee Documentation Committee wit

SUBMITTER: Colombini A 

PROVIDER: S-EPMC12310092 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature