Differential Crosslinking and Contractile Motors Drive Nuclear Chromatin Compaction.

ABSTRACT: During interphase, a typical cell nucleus features spatial compartmentalization of transcriptionally active euchromatin and repressed heterochromatin domains. In conventional nuclear organization, euchromatin predominantly occupies the nuclear interior, while heterochromatin, which is approximately 50% more dense than euchromatin, is positioned near the nuclear periphery. Peripheral chromatin organization can be further modulated by the nuclear lamina, which is itself a deformable structure. While a number of biophysical mechanisms for compartmentalization within rigid nuclei have been explored, we study a chromatin model consisting of an active, crosslinked polymer tethered to a deformable, polymeric lamina shell. Contractile motors, the deformability of the shell, and the spatial distrib

SUBMITTER: Theeyancheri L 

PROVIDER: S-EPMC12310140 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature