Temporal characterization of the gut microbiome and metabolome in preterm infants.

ABSTRACT: Preterm infants experience abnormal microbial colonization, which coupled with their vulnerable physiology can increase the risk of disease. Understanding the factors influencing the complex relationship between the temporal development of the gut microbiome and functional metabolites derived from microbe-microbe and microbe-host interaction is therefore critical. In this study, 266 longitudinal stool samples from 66 very preterm infants underwent 16S rRNA gene sequencing to analyse gut microbial structure. To further explore the functional status of these gut members, a subset of these samples underwent stool metabolomics (n=101). Statistically significant associations were found with age for both the gut microbiota (P<0.001) and metabolite profiles (P<0.001). Relatio

SUBMITTER: Beck LC 

PROVIDER: S-EPMC12310240 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature