Bone morphogenetic protein 10 is increased in pre-capillary pulmonary hypertension patients.

ABSTRACT:

Aims

Pre-capillary pulmonary hypertension (precPH) results in increased right atrial (RA) stretch and pressure. The right atrium is the major source of bone morphogenetic protein 10 (BMP10) in adults, primarily produced by RA cardiomyocytes. The aim of this study was to investigate BMP10 expression in the right heart and systemic circulation and to identify potential triggers for increased BMP10 secretion associated with precPH.

Methods and results

We examined BMP10 mRNA and protein expressions in RA tissue. Circulating BMP10 plasma levels were determined using enzyme-linked immunosorbent assay. BMP10 transcriptional activity was studied using a BMP-responsive element luciferase assay. Correlation analyses were performed between circulating BMP10 and RA dilatation as well as

SUBMITTER: Llucia-Valldeperas A 

PROVIDER: S-EPMC12310281 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature