Association Between Dysmenorrhea and Endometrial Cancer: A Mendelian Randomization Study.

ABSTRACT: Background: Dysmenorrhea is a common gynecological symptom among reproductive-aged women, associated with substantial pain and decreased quality of life. Previous studies have suggested that inflammatory and hormonal fluctuations linked to dysmenorrhea may influence endometrial cancer (EC) risk though causality remains uncertain. This study aimed to investigate potential causal relationships between dysmenorrhea (including pain severity, analgesic use, endometriosis, and related pelvic pain) and EC risk using a Mendelian randomization (MR) approach. Methods: A two-sample MR analysis was conducted using genome-wide association study (GWAS) data, selecting single nucleotide polymorphisms (SNPs) significantly associated with dysmenorrhea to assess EC risk. Primary analysis was p

SUBMITTER: Huang Q 

PROVIDER: S-EPMC12310317 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature