Trends in epilepsy mortality of three incidence cohorts across 2006-2023 in Sweden: a matched register-based study.

ABSTRACT:

Background

Idiopathic epilepsy alone accounts for a large health burden as shown in the Global Burden of Diseases Study. In countries with ageing populations, secondary epilepsies are now even more common. Altered clinical practice and reduced use of older enzyme-inducing drugs may be beneficial, but understanding of trends in the prognosis of all epilepsy is needed. Our objective was to determine and study trends in mortality in persons with epilepsy in Sweden through 2006-2023.

Methods

We performed a matched cohort study by cross-referencing National Patient, Drug, and Cause of Death Registers. We included all persons with a diagnosis of epilepsy and antiseizure medication (ASM) after 2006 (n = 61,375) and three age-/sex-matched comparators/case. Mortality was assessed for

SUBMITTER: Zelano J 

PROVIDER: S-EPMC12310390 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature