The relationship between riboflavin and hypertension with MTHFR C677T in older adults in northern China: a case-control study.

ABSTRACT:

Background and objectives

The incidence of hypertension is higher in individuals with the methylenetetra-hydrofolate reductase (MTHFR) 677TT genotype. Riboflavin serves as a coenzyme of MTHFR, but its role in hypertension prevalence is poorly understood. This study aimed to explore the relationship between riboflavin levels and hypertension and the impact of genotype on this relationship.

Methods and study design

The case-control study used data from the Tianjin Elderly Nutrition and Cognition study, with 200 hypertensive patients and 200 matched non-hypertensive controls. It collected questionnaires, clinical data, and measured blood riboflavin levels using the dried blood spot technique. Conditional logistic regression analyzed varia-bles related to hypertension prevalence

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12310434 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature