Exosome circ-CBLB promotes M1 macrophage polarization in rheumatoid arthritis through the TLR3/TRAF3 signaling axis.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a chronic autoimmune condition characterized by persistent inflammation of the joint's synovial membrane. This inflammation leads to the degradation of joint cartilage and bone, resulting in joint dysfunction and deformity. Early symptoms of RA are often subtle, complicating timely diagnosis. Identifying potential markers for RA is therefore critical.

Purpose and study design

This study aimed to explore the role of circular RNA CBLB (circ-CBLB) in RA by examining its influence on the Toll-like receptor 3/TNF receptor-associated factor 3 (TLR3/TRAF3) signaling axis and its effects on macrophage polarization through exosomes.

Results

We found that exosomes may contribute to macrophage polarization, as shown through exosome uptake

SUBMITTER: Zhang M 

PROVIDER: S-EPMC12310475 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature