Adverse childhood experiences influence markers of neurodegeneration risk in older adults.

ABSTRACT:

Introduction

Adverse childhood experiences (ACEs) disrupt brain development and increase vulnerability to Alzheimer's disease and related dementias (ADRD). We explored how ACEs impact neuroimaging, plasma biomarkers, and cognition in older adults.

Methods

Data from 214 participants aged ≥ 55 years were analyzed using linear and logistic regression, adjusting for demographic covariates.

Results

Financial need associated negatively with Montreal Cognitive Assessment scores (β = -0.10, p = 0.011). Lower mean diffusivity across white matter tracts associated with parental violence (β = -0.01, p = 0.03). Lower glial fibrillary acidic protein associated with parental intimidation (β = -0.07, p = 0.01) and parental violence (β = -0.18, p = 0.006). Family problems and separat

SUBMITTER: Rose DK 

PROVIDER: S-EPMC12310557 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature