The restriction impacts of the Type III restriction-modification system on the transmission dynamics of antimicrobial resistance genes in <i>Campylobacter jejuni</i>.

ABSTRACT:

Introduction

The spread of antibiotic resistance genes among Campylobacter jejuni (C. jejuni) is a serious problem, and the effects of the restriction-modification (R-M) system on the transmission dynamics of these genes in C. jejuni remain poorly understood.

Materials and methods

Complete genome sequences of C. jejuni strains were extracted from the BV-BRC database until March 25, 2024. The phylogenetic and the resistance analysis were used to analyze the distribution of resistance genes in C. jejuni. The impacts of the R-M systems on the AMR genes transmission between C. jejuni strains and the possible mechanisms were explored through recombination, pangenome and mobile genetic elements analysis.

Results

C. jejuni str

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC12310575 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature