Orthostatic hypotension in Parkinson's disease: effects on clinical features and disease severity-a systematic review and meta-analysis.

ABSTRACT:

Background

Parkinson's disease (PD) is often associated with orthostatic hypotension (OH). However, research examining the relationship between OH and PD has yielded inconsistent results. This study conducts a meta-analysis to determine the associations between OH and clinical characteristics in individuals with PD.

Methods

A systematic review and meta-analysis were performed by searching for studies related to PD and OH in the PubMed, Web of Science, Embase, and Cochrane databases. Data were pooled as necessary to calculate the odds ratios (OR) and weighted mean differences (WMD) with 95% confidence intervals (CI) for OH in PD patients. Heterogeneity was assessed using the I² statistic. Meta-regression was conducted to detect the potential influences of disease d

SUBMITTER: Wang H 

PROVIDER: S-EPMC12310585 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature