Features of Celiac Disease in children and adolescents with Down syndrome: a single-center experience of annual screening.

ABSTRACT:

Introduction

Coeliac disease (CD) manifests more frequently in individuals with Down syndrome (DS) and its prevalence varies across different studies. This study aims to assess the prevalence of CD in children with DS and to describe their clinical, serological, and histological features. A secondary aim was to analyze the time needed for the normalization of anti-transglutaminase IgA (TGA-IgA) and anti-endomysium IgA (EMA-IgA) levels in DS compared to non-syndromic (NS) children.

Materials and methods

This retrospective monocentric cohort study included patients with DS under 18 years of age, diagnosed with CD between 2005 and 2022. Each DS patient was matched for year of birth and sex with two NS celiac children. Follow-up was 6-, 12- and 24-months post-diagnosis.

Resul

SUBMITTER: Lattuada M 

PROVIDER: S-EPMC12310593 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature