Circulating miRNAs as potential non-invasive biomarkers for ANCA-associated glomerulonephritis.

ABSTRACT:

Introduction

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by necrotizing small vessel vasculitis that frequently manifests as glomerulonephritis (AAV-GN). An accurate noninvasive biomarker reflecting active AAV-GN remains elusive. The knowledge of microRNAs (miRNAs), which have been considered as disease-specific biomarkers, is scarce and lacks validated data in AAV.

Methods

This study validated a renal tissue expression profile of candidate miRNAs specific to AAV-GN selected through prior screening using independent cohorts. The analysis was extended to serum samples to explore the potential of a circulating miRNA panel as a noninvasive biomarker for active AAV-GN. To substantiate the findings, we correlated the molecular data wit

SUBMITTER: Bosnjak M 

PROVIDER: S-EPMC12310630 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature