HIV infection drives proinflammatory adipocyte differentiation in an <i>in vitro</i> model and reveals a new inflammatory pathway.

ABSTRACT:

Introduction

Adipose tissue regulates metabolic homeostasis and serves as a reservoir for mesenchymal stem cells (MSCs), which differentiate into osteoblasts and adipocytes, balancing bone and lipid metabolism. Bone loss and fat accumulation are common in individuals living with HIV, prompting us to investigate how R5- and X4-tropic HIV modulates adipocyte differentiation and tissue homeostasis using an in vitro model of MSC-derived adipogenesis.

Methods

The study used an in vitro model of MSCs to examine how R5- and X4-tropic HIV strains affect adipocyte differentiation and function. Researchers assessed adipogenesis by analyzing lipid droplet formation, expression of adipogenic transcription factors (C/EBPα, C/EBPβ, PPAR-γ), lipogenic/lipolytic enzymes, SREBPs, cyto

SUBMITTER: Freiberger RN 

PROVIDER: S-EPMC12310648 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature