Estimated glucose disposal rate and non-HDL-c/HDL-c ratio with the progression of carotid atherosclerosis: a long-term cohort study.

ABSTRACT:

Background

Both the estimated glucose disposal rate (eGDR) and the non-HDL-c/HDL-c ratio (NHHR) are associated with cardiovascular disease risk and prognosis. It is unclear whether assessing eGDR and NHHR together improves CAS progression prediction.

Methods

This large cross-sectional and longitudinal cohort study included 7,360 adults who underwent multiple health check-ups at the Chinese PLA General Hospital from October 2009 to December 2023. The relationships of the eGDR and NHHR with CAS progression were determined through multivariable Cox regression analysis and restricted cubic splines (RCS).

Results

During a median follow-up period of 30 months, we included 7,360 participants. The restricted cubic spline curve of the correlation between the eGDR and CAS progr

SUBMITTER: Han B 

PROVIDER: S-EPMC12310652 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature