Gut microbiome and serum metabolome alterations in osteosarcoma patients.

ABSTRACT:

Background

Gut microbiota has been shown to initiate tumorigenesis and cancer metastasis in multiple cancer types. However, the functional alterations of gut microbiota and their association with metabolism in osteosarcoma patients remain largely unexplored. This study aimed to characterize the gut microbiota and serum metabolite profiles in osteosarcoma patients, evaluate the diagnostic potential of gut microbiota and serum metabolites for osteosarcoma, and explore their correlations.

Methods

We collected 128 fecal and 181 serum samples from osteosarcoma patients, paired with matched healthy controls. 16S rRNA sequencing and untargeted metabolomics were applied to analyze gut microbiota and serum metabolism with significantly altered abundance in patients with osteosarcoma.

SUBMITTER: Li C 

PROVIDER: S-EPMC12310664 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature