Risk factors for mortality in anti-MDA5 antibody-positive dermatomyositis with interstitial lung disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis with interstitial lung disease (MDA5⁺ DM-ILD) carries a high mortality risk. This meta-analysis aimed to identify mortality risk factors to guide early clinical intervention.

Methods

Following PRISMA guidelines, we systematically searched PubMed, Embase, Web of Science, and Scopus for studies published before November 18, 2024. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated for mortality risk factors. Heterogeneity, sensitivity, and publication bias were assessed using Cochran's Q, one-by-one elimination, and Egger's tests, respectively.

Results

Among 1,153 patients from 15 studies, significant risk factors for mortality includ

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12310698 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature