Research on biliary atresia and epigenetic factors from the perspective of transcriptomics: identification of key genes and experimental validation.

ABSTRACT:

Background

Biliary atresia (BA) is a severe pediatric liver disease. However, the role of epigenetic factors in its pathogenesis remains poorly understood. This study aimed to identify key genes associated with BA and epigenetic factors, as well as to explore potential therapeutic drugs, thereby offering new insights into the treatment of this condition.

Methods

Transcriptomic datasets (training set GSE122340 and validation set GSE46960) were analyzed. The training set was used to identify differentially expressed genes (DEGs) between BA and normal samples. Candidate genes were selected by intersecting the DEGs with epigenetic factor-related genes. A protein-protein interaction (PPI) network was constructed, and key genes displaying consistent expression patterns across both

SUBMITTER: Na Z 

PROVIDER: S-EPMC12310709 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature