Emerging B and plasma cell-targeting immune therapies in idiopathic inflammatory myopathies.

ABSTRACT: Autoantibodies play a crucial role in the diagnosis and clinical characterization of idiopathic inflammatory myopathies (IIM). These antibodies are categorized into myositis-specific autoantibodies (MSAs), which are unique to IIM, and myositis-associated autoantibodies (MAAs), which can be seen with other autoimmune diseases. Both plasmablasts and plasma cells contribute to the production of these autoantibodies. Current B cell-targeted therapies, such as rituximab, have shown promise in refractory IIM, although their limitations - particularly in targeting plasmablasts and plasma cells - highlight the need for alternative agents with greater efficacy. This review discusses the evolving landscape of B cell and plasma cell-targeted immunotherapies in IIM, including next-generation anti-CD20

SUBMITTER: Groener M 

PROVIDER: S-EPMC12310725 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature