Longitudinal Brain Structural, Neurochemical, and Behavioral Changes Following Traumatic Brain Injury in Immature Rat Brain with ALCAR Treatment.

ABSTRACT: Pediatric survivors of traumatic brain injury (TBI) suffer from long-term neurologic disabilities, including deficits in memory and learning. Proton magnetic resonance spectroscopy (¹H-MRS) can assess alterations in brain neurochemical profile non-invasively in vivo over time. Our study aimed to evaluate (1) the longitudinal metabolic alterations in the hippocampus after TBI using in vivo ¹H-MRS and MRI in developing rat brain, and (2) test whether treatment with acetyl-L-carnitine (ALCAR) affects hippocampal metabolic profile. Using a controlled cortical impact model of TBI, we used post-natal day (PND) 21 rat pups and acquired longitudinal ¹H-MRS of the ipsilateral perilesional and contralateral hippocampi 2-4 h, 24 h, 72 h, 7 days, and 21 days post injur

SUBMITTER: Scafidi S 

PROVIDER: S-EPMC12310762 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature