Comparative survival outcomes of minimally invasive versus open radical nephroureterectomy for upper tract urothelial carcinoma in Taiwan.

ABSTRACT:

Purpose

Upper tract urothelial carcinoma (UTUC) is rare globally but accounts for 30-40% of urothelial cancers in Taiwan. Radical nephroureterectomy (RNU) with bladder cuff excision (BCE) remains the standard of care for localized or locally advanced disease. Despite the increasing adoption of minimally invasive surgical (MIS) approaches, concerns about their oncological outcomes persist. This study evaluates the comparative survival outcomes of MIS versus open RNU for UTUC using propensity-score-matched (PSM) analysis.

Methods

Data from 2430 patients with UTUC, treated between 1988 and 2022 within the Taiwan UTUC Collaboration Group, were retrospectively analyzed. PSM was employed to minimize baseline differences. The primary endpoints were overall survival (OS), cancer-spe

SUBMITTER: Chen IA 

PROVIDER: S-EPMC12310803 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature