Gut microbiome differences after vaginal birth in relation to rupture of membranes at term: a prospective longitudinal cohort study of twins.

ABSTRACT: The purpose of this study is to investigate the impact of intrapartum events, such as rupture of membranes and vaginal examinations, on the infant gut microbiome in twins born vaginally. This prospective longitudinal cohort study included pregnant women with twin pregnancies beyond 36 weeks of gestation undergoing vaginal births. Stool samples were collected from newborns on days 4 and 28 for gut microbiome analysis using 16S rDNA sequencing. The infants were followed for at least 1 year. Forty babies were followed in this study. Gestational age at birth was 37.07 (36.75-37.57) weeks. Significant differences were observed between the first and second twins in the number of vaginal examinations (5.50 (4.00-7.25) vs. 1.00 (1.00-1.00), P < 0.001) and the rupture of membranes to birth time (52

SUBMITTER: Cuerva MJ 

PROVIDER: S-EPMC12310857 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature