RabE1a- and SEC10b-mediated exocytosis and AP2β-mediated endocytosis are involved in the intracellular transport of tobamoviruses.

ABSTRACT: To establish systemic infection, plant viruses must replicate, and conduct intra- and intercellular movement and long-distance movement, all of which require the participation of host factors. Tobamoviruses move in the form of movement protein (MP)-viral RNA complex and utilize endocytosis for intracellular movement. However, how tobamoviral MPs hijack host factors to reach the plasma membrane (PM) and then plasmodesmata (PD) is still largely unknown. Tomato brown rugose fruit virus (ToBRFV) is an emerging tobamovirus that mainly infects tomatoes and peppers. Here, we show that tomato RabE1a, a small Rab GTPase, interacts with ToBRFV MP and participates in the movement of ToBRFV. Knocking out RabE1a in tomatoes could inhibit infection by ToBRFV. RabE1a positively regulates MP transport to

SUBMITTER: Ma HY 

PROVIDER: S-EPMC12310877 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature