Thrombolytic therapy of human black hair and Au drug-loaded nanocapsules in vivo and in vitro based on near infrared II laser response.

ABSTRACT: Venous thromboembolism ranks as the third most prevalent cardiovascular disease. Nanotechnology-based drug carriers show significant potential for thrombolytic therapy. However, existing systems face challenges, including environmental impact and limited accessibility. To address these, we developed a novel delivery system using human black hair-derived nanoparticles (HNPs). These HNPs were loaded with the thrombolytic agent urokinase plasminogen activator (uPA) and a minimal concentration of gold nanoparticles (AuNPs). These components were encapsulated within a polyvinyl alcohol (PVA) membrane to create the nanocapsule drug delivery system, uPA-Au@HNP@PVA. Upon intravenous injection into a rat model with venous thrombosis, the system leveraged targeted blood flow to reach thrombus sites.

SUBMITTER: Fang C 

PROVIDER: S-EPMC12310884 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature