Profiling the impact of different tau species on glial cell biology.

ABSTRACT:

Introduction

Tauopathies are a heterogeneous group of neurodegenerative disorders characterized by abnormal tau protein accumulation in neuronal and/or glial cells. Different pathogenic tau mutations result in distinct patterns of tau deposition, yet the differential effects of these tau species on glial cell biology are poorly understood. This study examines glial cell function in response to two distinct tau variants: P301L (promoting insoluble/fibrillar tau) and A152T (favoring soluble/oligomeric tau).

Methods

We used adeno-associated virus to express human tau containing either the P301L or A152T mutation and delivered to the brain by intracerebroventricular injection on postnatal day 0. At 3 months of age, we used the nCounter mouse glial profiling panel to measure expr

SUBMITTER: Arribas Gomez I 

PROVIDER: S-EPMC12310919 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature