Evaluating the potential of phenotypic age to enhance cardiovascular risk prediction over chronological age in the UK Biobank.

ABSTRACT: Phenotypic age acceleration (PhenoAgeAccel) is a novel biological indicator estimates an individual's mortality risk. The primary aim of this study was to evaluate the association between PhenoAge and PhenoAgeAccel with incident cardiovascular diseases (CVD) in the UK Biobank cohort. We analyzed data from 114,517 UK Biobank participants free of CVD history at baseline. PhenoAgeAccel of was obtained by regressing PhenoAge on chronological age (ChronoAge). We applied a Cox regression model with time-dependent variables to assess the association between PhenoAgeAccel and incident CVD. The predictive value of PhenoAge and PhenoAgeAccel was evaluated with reference to the Framingham Risk Score (FRS) model using Kaplan-Meier curves, receiver operating characteristic curves (AUC), and Harrel's C-

SUBMITTER: Kwan KJS 

PROVIDER: S-EPMC12310943 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature