Physiologic model of the cerebrovascular system using supply and demand between arteries and tissues.

ABSTRACT: Image-based modeling heavily relies on boundary conditions to obtain realistic blood flow and pressure. For the cerebrovascular system, boundary conditions are derived using in-vivo measurements or geometry-based models such as Murray's law, but these are constrained by the image resolution or high sensitivity to the segmented geometry. We propose a physiologic model of the cerebrovascular system based on a supply and demand relationship between arteries and tissues. Blood flow and perfusion territory are determined by associating brain tissues with nearby vessels using Voronoi tessellation. The model was evaluated for 40 healthy young individuals and two diseased patients, and was validated by comparing the estimated blood flows and perfusion territories against literature data and perfus

SUBMITTER: Lee CM 

PROVIDER: S-EPMC12310993 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature