Exercise-induced lactate suppresses ccRCC via CNDP2-mediated depletion of intracellular amino acids.

ABSTRACT: Although epidemiological evidence has established a link between physical exercise and reduced risk and recurrence of multiple cancers, the association between physical exercise and cancer risk varies depending on the cancer site. Therefore, there is an urgent need to explore the molecular mechanisms underlying the antitumor effects of exercise to identify which types of cancers can benefit the most from physical exercise. Recent studies have shown that amino acids and exercise-induced lactate can be used by Carnosine Dipeptidase 2 (CNDP2) to synthesize lactoyl amino acids (Lac-AAs), which are then immediately secreted. Thus, we propose that lactate can deplete intracellular amino acids in a CNDP2-dependent manner, thereby exerting antitumor effects. Further bioinformatics analysis reveale

SUBMITTER: Miao R 

PROVIDER: S-EPMC12310999 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature