Biochemical characterization of a novel purified lectin extracted from Pleurotus ostreatus mushroom for its antiviral activity.

ABSTRACT: Viruses are responsible for numerous serious outbreaks and pandemics worldwide. In this context, lectins, which are carbohydrate-binding proteins, have garnered attention due to their antiviral properties against RNA and DNA viruses. The antiviral potential of the purified and well-characterized lectin from Pleurotus ostreatus (POL) was assessed against various viruses. POL showed potent antiviral activity against HCV with IC₅₀ values of 68.75 nM and 52.13 nM for determining the blocking and neutralizing infectivity, respectively. POL exhibited IC₅₀ values of 42.75 and 14.88 nM against HBV through treatment and blocking mechanisms, respectively. Notably, POL demonstrated a 58.80% binding capacity to cell-surface CD81, while the IC₅₀ values for targeting the

SUBMITTER: El-Maradny YA 

PROVIDER: S-EPMC12311003 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature