Representational drift as the consequence of ongoing memory storage.

ABSTRACT: Memory systems with biologically constrained synapses have been the topic of intense theoretical study for over thirty years. Perhaps the most fundamental and far-reaching finding from this work is that the storage of new memories implies the partial erasure of already-stored ones. This overwriting leads to a decorrelation of sensory-driven activity patterns over time, even if the input patterns remain similar. Representational drift (RD) should therefore be an expected and inevitable consequence of ongoing memory storage. We tested this hypothesis by fitting a network model to data from long-term chronic calcium imaging experiments in mouse hippocampus. Synaptic turnover in the model inputs, consistent with the ongoing encoding of new activity patterns, accounted for the observed statisti

SUBMITTER: Devalle F 

PROVIDER: S-EPMC12311018 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature