Genome-wide analysis in human populations reveals mitonuclear disequilibrium in genes related to neurological function.

ABSTRACT: Mitonuclear disequilibrium (MTD), defined as the non-random association of nuclear and mitochondrial alleles, is a form of gametic disequilibrium that may arise from coevolutionary adaptation between nuclear and mitochondrial genes interacting to maintain the efficiency of mitochondrial function. Intrinsic and extrinsic factors influence the outcome of this evolutionary process in which compatible alleles of the nuclear and mitochondrial counterparts are co-selected during population divergence. In humans, MTD has not been investigated deeply. Here, we present a genome-wide high-resolution analysis of 2,490 previously published human genomes from the 1000 Genomes Project database. By combining formal testing and simulations to discard random and population effects, we identified 669 nuclea

SUBMITTER: Gonzalez-Orozco E 

PROVIDER: S-EPMC12311052 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature