Association of serum urea-to-creatinine and creatinine-to-cystatin C ratios with bone mineral density and osteoporosis: a cross-sectional study.

ABSTRACT: Sarcopenia and osteoporosis are two closely related degenerative diseases, and the urea-to-creatinine ratio (UCR) and creatinine-to-cystatin C ratio (CCR) have been reported as recognized muscle markers. Therefore, this study aims to investigate the relationship between muscle indicators (UCR and CCR) and bone mineral density (BMD), and osteoporosis prevalence. This cross-sectional study included 1,146 participants, of whom 363 were diagnosed with osteoporosis. Through regression and smooth curve fitting analysis, after adjusting for covariates, it was revealed that UCR was positively correlated with the risk of osteoporosis (OR = 1.020, 95% CI 1.011-1.029), and negatively correlated with BMD of lumbar spine (β = - 0.002, 95% CI - 0.002 to - 0.001), total hip (β = - 0.001, 95% CI - 0.002 t

SUBMITTER: Shao L 

PROVIDER: S-EPMC12311058 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature