Impact of allogeneic dental pulp stem cell injection on tissue regeneration in periodontitis: a multicenter randomized clinical trial.

ABSTRACT: Periodontitis causes the destruction of tooth-supporting tissues, and current therapies for periodontal regeneration are invasive. In this study, a human dental pulp stem cell (DPSC; hDP-MSC) injection was developed to promote periodontal regeneration through a non-invasive procedure. A total of 132 patients with chronic periodontitis (158 teeth) from two centers in China were included. Thirty-six were randomly assigned to different DPSC dose groups (ranging from 1 × 10⁶ to 1 × 10⁷ DPSCs per tooth, with nine injected with saline only), and 96 were randomly assigned to a single-injection group (1 × 10⁷/0.6 mL DPSCs), a double-injection group (1 × 10⁷/0.6 mL DPSCs × 2), or a saline group, in a 1:1:1 ratio. At 6 months post-therapy, attachment loss

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12311062 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature