Motion correction of simultaneous brain PET/MR images based on tracer uptake characteristics.

ABSTRACT:

Background

Simultaneous PET/MR imaging enables precise anatomical localization and PET quantification by reducing PET-to-MR misalignments. However, involuntary motion during scans may still cause misalignment and quantification imprecision. Current mutual information (MI)-based co-registration methods do not account for the tissue-specific uptake patterns of PET and therefore could result in suboptimal alignment. To address this, we proposed a novel image co-registration method, namely the tracer characteristic-based co-registration (TCBC) method, which takes advantage of specific PET uptake patterns within a selected anatomical region to improve the image alignment and PET quantification.

Results

TCBC was evaluated using simulation and in vivo ¹⁸F-Florbetapir PET

SUBMITTER: Chiu SC 

PROVIDER: S-EPMC12311070 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature