Characterization and genomics of phage Henu2_3 against K1 Klebsiella pneumoniae and its efficacy in animal models.

ABSTRACT: The emergence and spread of multidrug-resistant and super-resistant bacterial strains have positioned phage therapy as a highly promising approach for future infection treatments. Klebsiella pneumoniae, a leading cause of clinical infections and hospital-acquired diseases, is responsible for over 95% of infections within the Klebsiella genus. Phages targeting K. pneumoniae exhibit remarkable diversity, with numerous isolates identified against various serotypes of this pathogen. In this study, we described the isolation and characterization of a novel bacteriophage from hospital sewage, Henu2_3, which targeted clinical isolates of K1-type K. pneumoniae. Transmission electron microscopy revealed that phage Henu2_3 possessed an icosahedral head and podovirus morphotype. The phage genome comp

SUBMITTER: Li Q 

PROVIDER: S-EPMC12311074 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature