The longitudinal effects of global and regional brain measurements on cognitive abilities.

ABSTRACT: Loss of brain tissues and cognitive abilities are natural processes of aging, but longitudinal studies are limited. We explored the longitudinal association between global and regional brain measures with cognitive abilities among individuals with normal cognitive status, mild cognitive impairment, and Alzheimer's Disease, including those with stable or progressive cognitive status, from the Alzheimer's Disease Neuroimaging Initiative. Follow-up was conducted approximately every six months for two to three years to classify participants by their cognitive status (n = 814). Mixed effects models were used to measure the longitudinal association between global and regional brain measures with cognitive abilities assessed by the Alzheimer's Disease Assessment cognition sub-scale after controll

SUBMITTER: Hosseininasabnajar F 

PROVIDER: S-EPMC12311093 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature